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Comparison of the effect of intravenous ephedrine and atropine in the prevention of arterialhypotension and bradycardia after spinal anesthesia parallel clinicaltrial

Comparison of the effect of intravenous ephedrine and atropine in the prevention of arterialhypotension and bradycardia after spinal anesthesia parallel clinicaltrial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241102063564N1
Enrollment
156
Registered
2024-11-28
Start date
2024-12-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

arterial hypotension. Other hypotension

Interventions

Intervention 1: Intervention group A: Ephedrine 0.15 mg per kg will be injected immediately before spinal anesthesia for group A patients. The amount of injectable ephedrine per shift will be 0.15 mg/

Sponsors

Karaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: People aged 18 to 60 years absence of arterial hypertension absence of arrhythmia absence of bradycardia and tachycardia.

Exclusion criteria

Exclusion criteria: Taking beta blockers or calcium channel blockers for any reason taking cardiac drugs and blood pressure drugs primary systolic blood pressure more than 140 mmHg tachycardia HR>100 before anesthetic injection presence of ischemic heart disease Heart valve disease hyperthyroidism sensitivity to ephedrine or atropine bleeding during surgery is more than 10%

Design outcomes

Primary

MeasureTime frame
Arterial hypotension. Timepoint: Patients' blood pressure will be measured at baseline before spinal anesthesia and drug injection, then every 1 minute to 10 minutes, and then every 5 minutes to 45 minutes after drug injection. Method of measurement: Blood pressure monitoring of patients will be by NIBP (Non Invasive Blood Pressure) method.;Bradycardia. Timepoint: Patients' heart rate will be measured at baseline before spinal anesthesia and drug injection, then every 1 minute to 10 minutes, and then every 5 minutes to 45 minutes after drug injection. Method of measurement: heart rate monitoring of patients will be by NIBP (Non Invasive Blood Pressure) method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Mohsen Pouriagoubi

Karaj University of Medical Sciences

Ezati.maryam02@gmail.com+98 26 3443 4700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026