Effect of Persian medicine diet on male infertility

Investigating and comparison of the effect of diet based on the principles of Persian medicine and conventional medicine on sperm parameters, some inflammatory factors and oxidative stress, and sperm DNA fragmentation index in idiopathic infertile men

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241101063557N4

Enrollment

100

Registered

2025-11-28

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility. N46

Interventions

Intervention 1: Intervention group: (Day 1) Patients complete demographic and physical activity questionnaires as well as the Persian Traditional Medicine Diet Questionnaire. The required score for th

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Adults men with age of 18-45 years old Idiopathic abnormal spermogram in terms of sperm count, motility, morphology, or all according to World Health Organization criteria Consent to participate in the study Iranian nationality BMI 18.5-30

Exclusion criteria

Exclusion criteria: Addiction to alcohol and drugs azoospermia Anatomical infertility findings Cancers Thyroid disorders Heart disease, diabetes, and uncontrolled high blood pressure Use of chemotherapy drugs or corticosteroids, herbal medicines, hormonal drugs Activity in very hot environments Specific diets and vegetarianism

Design outcomes

Primary

Measure	Time frame
Determining and Comparing the Effect of a Diet Based on Persian Medicine Principles and Conventional Medicine on Sperm Parameters in Idiopathic Infertile Men. Timepoint: Measurement of semen parameters at the beginning and end of the third month after receiving dietary recommendations. Method of measurement: Semen analysis.	—

Secondary

Measure	Time frame
Determination and comparison of the effects of a diet based on the principles of Persian medicine and conventional medicine on inflammatory factors, oxidative stress, and sperm DNA fragmentation index in idiopathic infertile men, and potential side effects. Timepoint: Measurement of some inflammatory factors, oxidative stress, and sperm DNA breakage index at the beginning and end of the third month after receiving dietary recommendations. Method of measurement: Inflammatory factors and oxidative stress by ELISA (Enzyme Linked Immunosorbent Assay) method and sperm DNA breakage index by SCD (Sperm Chromatin Dispersion) method.	—

Measure

Time frame

Determination and comparison of the effects of a diet based on the principles of Persian medicine and conventional medicine on inflammatory factors, oxidative stress, and sperm DNA fragmentation index in idiopathic infertile men, and potential side effects. Timepoint: Measurement of some inflammatory factors, oxidative stress, and sperm DNA breakage index at the beginning and end of the third month after receiving dietary recommendations. Method of measurement: Inflammatory factors and oxidative stress by ELISA (Enzyme Linked Immunosorbent Assay) method and sperm DNA breakage index by SCD (Sperm Chromatin Dispersion) method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRamin Nasimi Doost Azgomi

Ardabil University of Medical Sciences

modir7060@yahoo.com+98 45 3353 4705

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026