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Investigating the effect of two combined drugs with metformin in women with polycystic ovary syndrome

Comparing the therapeutic effect of Melijent-M and Synoripa on infertile women with polycystic ovary syndrome undergoing Sperm intracytoplasmic injection

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241027063520N1
Enrollment
80
Registered
2024-11-17
Start date
2024-11-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Control group: with Oral rehydration solutions(ORS) (Porsina, placebo, Iran) twice a day for 8 weeks. Intervention 2: Intervention group: receiving metformin (500 mg twice a day) for 8

Sponsors

Arak University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 35 Years

Inclusion criteria

Inclusion criteria: Infertility due to polycystic ovary syndrome Patients with polycystic ovary syndrome aged 25 to 35

Exclusion criteria

Exclusion criteria: Patients with hypersensitivity to metformin Patients with hypersensitivity to dipeptidyl peptidase-4 inhibitors Patients with hypersensitivity to sodium glucose cotransporter-2 Male infertility Patients with congenital adrenal hyperplasia Patients with thyroid gland disorders Patients with Cushing's syndrome Patients with androgen secreting neoplasia Severe liver diseases Severe kidney diseases Patients with gallstones

Design outcomes

Primary

MeasureTime frame
Investigation of changes in biochemical factors in blood serum. Timepoint: Measurement of biochemical factors before the patient started taking the drug and 8 weeks after taking the drug on the day of puncture. Method of measurement: Using the ELISA kit.;Investigation of changes in hormonal factors in blood serum. Timepoint: Measurement of hormonal factors before the patient started taking the drug and 8 weeks after taking the drug on the day of puncture. Method of measurement: Using the ELISA kit.

Secondary

MeasureTime frame
The number of eggs obtained. Timepoint: On the day of puncture, the patient's egg count is checked. Method of measurement: Oocyte collection by ultrasound-guided transvaginal aspiration using a single-lumen needle.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdieh Sadat Mousavi

Arak University

ms.mousavi98@yahoo.com+98 54 3349 1574

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026