Evaluating the effect of N- N-acetylcysteine on triiodothyronine (T3) level, and early postoperative outcomes in cardiac surgery patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241027063514N1

Enrollment

Registered

2025-01-07

Start date

2025-12-01

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass cardiac surgery patients. atherosclerosis of coronary artery bypass grafts without angina pectoris

Interventions

Intervention 1: Intervention group: the group of the CABG patients how receive NAC. Intervention 2: Control group: the group of the CABG patients how receive normal saline as a placebo in stead of NA

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age more than 18 y Elective cardiac surgery Absence of exclusion criteria

Exclusion criteria

Exclusion criteria: Hypothyroidism Receiving thyroid medication Renal failure Hepatic failure Immunosuppressive drug use Receiving medium dose of the inotropes Moderate corticosteroid use

Design outcomes

Primary

Measure	Time frame
Triiodothyronine 3 level. Timepoint: Every day after procedure until 3 days. Method of measurement: Laboratory findings.;Intubation time. Timepoint: Hours of intubation. Method of measurement: Clinical findings.;Length of hospital stay. Timepoint: Days of stay in hospital. Method of measurement: Clinical outcomes.;Length of tracheal intubation. Timepoint: Duration based on hours. Method of measurement: Clinical outcomes.;Length of stay in ICU. Timepoint: Duration based on days. Method of measurement: Clinical.;One month mortality rate. Timepoint: Days. Method of measurement: Clinical.	—

Measure

Time frame

Triiodothyronine 3 level. Timepoint: Every day after procedure until 3 days. Method of measurement: Laboratory findings.;Intubation time. Timepoint: Hours of intubation. Method of measurement: Clinical findings.;Length of hospital stay. Timepoint: Days of stay in hospital. Method of measurement: Clinical outcomes.;Length of tracheal intubation. Timepoint: Duration based on hours. Method of measurement: Clinical outcomes.;Length of stay in ICU. Timepoint: Duration based on days. Method of measurement: Clinical.;One month mortality rate. Timepoint: Days. Method of measurement: Clinical.

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Secondary

Measure	Time frame
Erythrocyte sedimentation rate. Timepoint: Before surgery and daily up to 3 days. Method of measurement: Laboratory finding; Milliliter per hour.;C Reactive protein. Timepoint: Before surgery and daily up to 3 days. Method of measurement: Laboratory finding; Milligram per liter.;Dose of inotropes. Timepoint: During surgery and in ICU. Method of measurement: Microgram per kilogram per minute.;Rate of cerebral vascular accidents. Timepoint: In one month after operation. Method of measurement: Clinical diagnosis.;Pneumonia. Timepoint: From 48 hours after admission to 1 week after discharge from hospital. Method of measurement: clinical and paraclinical diagnosis.;Arrythmia. Timepoint: During ICU stay. Method of measurement: clinical and paraclinical diagnosis.;Wound infection. Timepoint: During hospital stay. Method of measurement: clinical and paraclinical diagnosis.	—

Measure

Time frame

Erythrocyte sedimentation rate. Timepoint: Before surgery and daily up to 3 days. Method of measurement: Laboratory finding; Milliliter per hour.;C Reactive protein. Timepoint: Before surgery and daily up to 3 days. Method of measurement: Laboratory finding; Milligram per liter.;Dose of inotropes. Timepoint: During surgery and in ICU. Method of measurement: Microgram per kilogram per minute.;Rate of cerebral vascular accidents. Timepoint: In one month after operation. Method of measurement: Clinical diagnosis.;Pneumonia. Timepoint: From 48 hours after admission to 1 week after discharge from hospital. Method of measurement: clinical and paraclinical diagnosis.;Arrythmia. Timepoint: During ICU stay. Method of measurement: clinical and paraclinical diagnosis.;Wound infection. Timepoint: During hospital stay. Method of measurement: clinical and paraclinical diagnosis.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhosro Barkhordari

Tehran University of Medical Sciences

kh.barkhordari@gmail.com+98 21 8802 9600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026