Lichen planus. Lichen planus
Conditions
Interventions
Intervention 1: Intervention group: Tablet Baricitinib 4 mg (Arena Haiat Company) Daily for 3 months. Intervention 2: Control group: Tablet Hydroxychloroquine 200mg every 12 hours (Amin Company) for
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Over 16 Years Old Lichen Planus Patients Who have Cutaneous Manifestations Glomerular Filtration Rate More than 60
Exclusion criteria
Exclusion criteria: Pregnant Mothers Lactating Mothers Hepatic Failure Renal Failure Treated with Topical or Systemic Steroid 1 Year Before the Study Past History of Cerebrovascular Attack Past History of Myocardial Infarction Past History of Deep Vein Thrombosis Past History of Pulmonary Thromboembolism Past History of Peptic Ulcer Disease Past History of leukemia Past History of lymphoma Past History of Bone Marrow Failure Past History of G6PD Deficiency Past History of Retinopathy Past History of Neuropsychiatric Diseases Past History of lymphopenia Past History of leucopenia Patient Reluctance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Pruritis. Timepoint: Evaluation of Severity of Pruritis at the Beginning of the Study (before starting the Intervention) , 2,and 3 months after starting Baricitinib. Method of measurement: Numerical Visual Analogue Scale(0-10). | — |
Secondary
| Measure | Time frame |
|---|---|
| Time it takes to Respond to Treatment. Timepoint: Evaluation of Response to Treatment at the Beginning of the Study (before starting the Intervention) , 2,and 3 months after starting Baricitinib. Method of measurement: Time it takes to Respond to Treatment ( by Weeks).;Physician Global Assessment. Timepoint: Physician Global Assessment at the Beginning of the Study (before starting the Intervention) , 2,and 3 months after starting Baricitinib. Method of measurement: Physician Global Assessment Table.;Lichen planus Activity and Damage Index. Timepoint: Lichen planus Activity and Damage Index at the Beginning of the Study (before starting the Intervention) , 2,and 3 months after starting Baricitinib. Method of measurement: Lichen planus Activity and Damage Index Table.;Patient Satisfaction. Timepoint: Evaluation of Patient Satisfaction at the Beginning of the Study (before starting the Intervention) , 2,and 3 months after starting Baricitinib. Method of measurement: Numerical Visual Analogue Scale (0-10). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Kargar
Shiraz University of Medical Sciences
Outcome results
None listed