Skip to content

Effect of topical Sildenafil on the success rate of skin grafts

Investigation of the effect of topical Sildenafil on the success rate of skin grafts in burn patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241024063488N3
Enrollment
120
Registered
2025-11-16
Start date
2025-12-22
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burns. Burns and corrosions

Interventions

Intervention 1: Intervention group: Recipient of topical sildenafil dressing. In each individual, the respective burn will be divided into two parts
in other words, the intervention and control will be performed on the same patient at the same time. The intervention group will receive tetracycline ointment along with a 1% sildenafil gel in a 10 x
in other words, the intervention and control will be performed on the same patient at the same time. The control group will receive only the usual dressing of the required size using tetracycline.

Sponsors

Artesh University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with deep second-degree burns requiring skin grafting Patients have at least 200 cm2 of burns of the same degree. Age range 15 to 65 years

Exclusion criteria

Exclusion criteria: Having any underlying disease including diabetes, hypertesion, etc.

Design outcomes

Primary

MeasureTime frame
Graft success rate based on capillary refill. Timepoint: Two weeks after intervention. Method of measurement: Clinical examination of burn patients.;Graft success rate based on color. Timepoint: Two weeks after intervention. Method of measurement: Clinical examination of burn patients.;Graft success rate based on revascularization. Timepoint: Two weeks after intervention. Method of measurement: Clinical examination of burn patients.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahryar Sadeghi

Artesh University of Medical Sciences

roa00011@gmail.com+98 21 8609 6350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026