The efficacy of prophylactic oral calcium and vitamin D therapy in controlling early postoperative complications of hypocalcemia in thyroidectomy patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241023063478N1

Enrollment

Registered

2024-12-02

Start date

2024-12-07

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Malignant neoplasm of thyroid gland. Condition 2: Nontoxic multinodular goitre. Malignant neoplasm of thyroid gland Nontoxic multinodular goiter

Interventions

Intervention 1: Intervention group or group receiving vitamin D and calcium: administration of a dose of 1 gram of calcium carbonate every eight hours to 48 hours after surgery. Also, the administrati

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The entry criteria for each group is total thyroidectomy surgery Normal calcium before surgery (within the normal range of 10.4-8 mg/dl)

Exclusion criteria

Exclusion criteria: Patients whose preoperative calcium is outside the normal range (outside the range of 8 to 10.4 mg/d). Patients who have previously undergone thyroid lobectomy. Patients with a history of allergic reactions to study drugs. Patients who develop drug reactions following oral calcium and vitamin D intake during hospitalization. Lack of proper cooperation or dissatisfaction of patients during follow-up or at any stage of hospitalization and study. Patients with known cases of osteoporosis and osteopenia, renal failure, and hyperparathyroidism.

Design outcomes

Primary

Measure	Time frame
Clinical tests of calcium loss. Timepoint: 0-6-12-24-36-48 hours after the operation. Method of measurement: Positive and negative test of Chvostek and Trousseau.;Loss of calcium after surgery. Timepoint: 0-6-12-24-36-48 hours after the operation. Method of measurement: Blood calcium less than 7.5 mg/dl after surgery or blood calcium less than 8 mg/dl after surgery with clinical symptoms.	—

Secondary

Measure	Time frame
Clinical signs. Timepoint: 0- 6-12- 24- 36- 48 hours after the operation. Method of measurement: The presence or absence of symptoms such as convulsions, spasms, numbness and tingling of the limbs and around the lips.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajjad omidi

Bagheiat-allah University of Medical Sciences

Omidi.sajjadi@gmail.com+98 21 8805 0435

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026