Comparison of the effect of acetylcysteine ??and tranexamic acid on occult blood loss in knee arthroplasty

A comparative study of the effects of N-acetylcysteine and tranexamic acid on hidden blood loss in knee arthroplasty

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241023063471N1

Enrollment

204

Registered

2024-11-02

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Unilateral primary osteoarthritis of knee

Interventions

Intervention 1: Intervention group: In the first group, they receive 25 mg/kg of N-acetylcysteine ??once every 8 hours as a intravenous injection one day before surgery and then 10 mg/kg every 8 hours

Eligibility

Sex/Gender

All

Age

50 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients eligible for knee arthroplasty Age 50-90 years

Exclusion criteria

Exclusion criteria: History of anemia Liver disease Coagulation disorders

Design outcomes

Primary

Measure	Time frame
Occult bleeding rate. Timepoint: One day before the operation - the day of the operation - one day after the operation. Method of measurement: Check hemoglobin levels before and after surgery based on the Maximum Allowable Blood Loss formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahid Daman Pak

Ghoum University of Medical Sciences

Vahid65037@gmail.com+98 25 3612 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026