The effect of mouthwash on colonization and incidence of ventilator-associated pneumonia

The effect of mouthwash with eucalyptus and chlorhexidine on bacterial colonization of the mouth and pharynx and incidence of ventilator-associated pneumonia in mechanically ventilated

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241021063449N1

Enrollment

105

Registered

2025-11-21

Start date

2024-10-25

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated pneumonia. Unspecified acute lower respiratory infection

Interventions

Intervention 1: First intervention group: In the first group, oral care and mouthwash with Irsha chlorhexidine %0/2 solution(10 cc) were used twice a day at an interval of every 12 hours (6 am and 6

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patient admitted to the intensive care unit Age 18 to 65 years Having an oral tracheal tube Having the informed consent Normal coagulation system

Exclusion criteria

Exclusion criteria: History of allergy to herbal compounds jaw and face trauma pregnancy Diagnosis of pneumonia on arrival

Design outcomes

Primary

Measure	Time frame
A score of more than 5 on the modified Clinical Pulmonary Infection Score. Timepoint: Check for pneumonia before starting the intervention and recheck 72 hours after mouthwash. Method of measurement: modified Clinical Pulmonary Infection Score.;Presence of microorganisms in patients' throat culture samples. Timepoint: Sending a throat culture sample before starting the intervention and re-examining 72 hours after mouthwash. Method of measurement: Culture samples from patients' throat secretions.	—

Measure

Time frame

A score of more than 5 on the modified Clinical Pulmonary Infection Score. Timepoint: Check for pneumonia before starting the intervention and recheck 72 hours after mouthwash. Method of measurement: modified Clinical Pulmonary Infection Score.;Presence of microorganisms in patients' throat culture samples. Timepoint: Sending a throat culture sample before starting the intervention and re-examining 72 hours after mouthwash. Method of measurement: Culture samples from patients' throat secretions.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Khodadadi

Rafsanjan University of Medical Sciences

akhodadadi67@gmail.com+98 34 3426 2818

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026