The effectiveness of Bromelain on swelling and bruise after eyelid plastic surgery

: The Effectiveness of Bromelain on Edema and Ecchymosis after Blepharoplasty: a Randomized, Triple-blind, Placebo-Controlled Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241021063440N1

Enrollment

154

Registered

2025-07-28

Start date

2024-10-26

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

edema and ecchymosis of eyelid. Inflammation of eyelid, unspecified

Interventions

Intervention 1: Intervention Group (Treatment): The study drug is bromelain capsules (200 mg, equivalent to 500 GDU) containing proteolytic enzymes extracted from pineapple, manufactured by Salamat P

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: People between the ages of 18 and 60 have undergone open methods of blepharoplasty. Failure to take dexamethasone during and after surgery Failing to use cold compresses after surgery Lack of hypertension and coagulation disorders Patient satisfaction in the participation in the study

Exclusion criteria

Exclusion criteria: History of allergy to bromelain or any of the components of the product

Design outcomes

Primary

Measure	Time frame
Extremeness of edema and ecchymosis. Timepoint: Determination the grade of edema and ecchymosis on days 1, 3, 7, 11 after surgery. Method of measurement: grading board.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBenyamin Rahmati

Arak University of Medical Sciences

benyamin.rahmaty@gmail.com0863813895

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026