status epilepticus. refractory status epilepticus
Conditions
Interventions
Intervention 1: Intervention group: Levetiracetam is administered over 5 minutes at a dose of 40 mg/kg, with a maximum dose of 2.5 grams. Following the initiation of injection, the patient is monitore
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
6 Months to 18 Years
Inclusion criteria
Inclusion criteria: Boys or girls aged 6 months to 17 years and 11 months The patient has received two consecutive doses of first-line treatment but continues to experience ongoing status epilepticus.
Exclusion criteria
Exclusion criteria: Patients with known or suspected pregnancy Patients with a known contraindication or allergy to Levetiracetam or Phenytoin Patients with known renal failure (patients undergoing hemodialysis or with renal function below 50% of the expected for their age) Prior administration of a second-line antiepileptic drug before admission to the emergency department Seizures following head trauma Individuals with underlying heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from the start of drug injection to the cessation of all visible signs of seizure activity, which is defined as the cessation of all rhythmic seizure activity. Timepoint: From the time of drug injection to the end of epileptic status. Method of measurement: using a stopwatch by the therapist. | — |
Secondary
| Measure | Time frame |
|---|---|
| The need for tertiary anticonvulsants to manage seizures after second-line therapy. Timepoint: After failure to respond to second-line therapy. Method of measurement: The number of patients who needed third-line treatment is recorded in each group. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad Ahmadabadi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed