acute gastroenteritis. Rotaviral enteritis
Conditions
Interventions
Intervention 1: Intervention group: The administration of pantoprazole at a dose of 2 mg/kg/day, which is given intravenously in two doses. Each vial contains 40 mg of pantoprazole and is administered
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
4 Months to 18 Years
Inclusion criteria
Inclusion criteria: age more than 4 months and less than 18 years old clinically diagnosed acute gastroenteritis patients with a mild to moderate degree of dehydration, where oral rehydration therapy has failed, and indication for hispitalization Oral feeding intolerance persistent vomiting despite ORT regimen ( one or more episodes of vomiting during the past 48 hours)
Exclusion criteria
Exclusion criteria: suspicion to acute abdomen history of any abdominal surgery Loss of contiousness fever history of metabolic disorder history of renal diseases, liver diseases, IBD, Immunodeficiency, DKA severe dehydration with or without shock Hypo/Hypernatremia dehydration corticosteroids consumption allergic history to PPT metabolic acidosis (Ph < 7.25) previous antibiotic use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of vomiting episodes within 24 hours after the start of treatment. Timepoint: Every 6 hours after the start of treatment. Method of measurement: According to the medical records and based on the number of episodes reported by nurses or the child’s parents within the specified time frame. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of dehydration and its changes during treatment. Timepoint: Before starting the treatment and 24 hours after treatment. Method of measurement: Using dehydration indices (such as clinical symptoms, the child’s weight, and urine output).;Duration of hospital stay. Timepoint: From the start of hospitalization to the patient’s discharge (measured in hours or days). Method of measurement: Information recorded in the hospital records.;Adverse effects of the drug (gastrointestinal, allergic, etc.). Timepoint: Adverse effects of the drug (gastrointestinal, allergic, etc.). Method of measurement: Monitoring patient complaints, recording clinical side effects by nurses, and documenting reported adverse effects in the medical records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNastaran Babajani
Tehran University of Medical Sciences
Outcome results
None listed