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Investigating the effect of aspirin in breast cancer

Comparison of the therapeutic effect of aspirin in combination with standard chemotherapy regimens compared to placebo in breast cancer

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241015063367N1
Enrollment
100
Registered
2024-12-16
Start date
2024-10-22
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer. Malignant neoplasm of breast

Interventions

Intervention 1: Intervention group: after obtaining informed consent and explaining the objectives of the research, aspirin 81 milligrams daily is given to the intervention group. Intervention 2: Con

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Women aged 18 to 70 with breast cancer who have been confirmed by histopathological diagnosis 2. Stage II to III who are candidates for neoadjuvant chemotherapy 3. Zero or on Eastern Cooperative Oncology Groupperformance index 4. Informed consent to enter the study

Exclusion criteria

Exclusion criteria: 1. Patients with a history of other malignancies, a history of myocardial infarction, a history of atrial fibrillation, and a history of grade hypertension 2. Contraindications of aspirin use 3. Simultaneous use of warfarin, heparin or heparin analogues, clopidogrel, thrombin inhibitors or coagulation factors 4. History of taking aspirin within 30 days before entering the study

Design outcomes

Primary

MeasureTime frame
Complete pathologic response. Timepoint: 4 month. Method of measurement: Pathology report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoghaye Abdollahi

Kerman University of Medical Sciences

roghayeabdollahi@yahoo.com+98 34 3132 8000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026