Head and neck cancers. Malignant neoplasm of nasopharynx
Conditions
Interventions
Intervention 1: Intervention group:Patients in the intervention group will be treated with a Silymarin solution (20 drops of the Silymarin solution from Zardband company, four times a day). The medica
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age 18 to 65 years old Karnofsky Performance Status (KPS) 70 or more than 70 (or ECOG=0-1) New case There is pathologic diagnosis on head and neck malignancies There is indication of adjuvant or definitive radiation therapy Minimum treatment dose of 60 GY At least half of oral cavity should be in the treatment field
Exclusion criteria
Exclusion criteria: Dissatisfication of patient for enter to the study Chronic renal ( eGFR3 upper limit of normal) disease History of previous malignancy History of previous radiation therapy on head and neck area History of hypersensitivity reaction to sylimarin Patient recieve induction chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grading of mucositis. Timepoint: The first fraction of radiotherapy, weekly during radiation therapy until two months after finishing the treatment. Method of measurement: World Health Organization grading system for mucositis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyede Simin Mirmohammadi Kiarash
Shiraz University of Medical Sciences
Outcome results
None listed