Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention Group 1: Administration of 20 mg duloxetine from two weeks before surgery until 14 days post-surgery and assessment of pain intensity before surgery, on day 14, and three
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age above 18 years hospitalized patients for knee replacement surgery: No major depressive disorder or other severe psychiatric disorders - No intellectual disability - No use of psychotropic medications in the last 8 weeks - No cognitive disorders such as dementia and delirium - No use of narcotics Having consent to participate in the study
Exclusion criteria
Exclusion criteria: Occurrence of drug allergy or severe drug adverse effects change in treatment regimen during the study for any reason Patients unable to take oral medications Pregnancy and breastfeeding Patient's refusal to participate in the study Drugs that interact with duloxetine and memantine Cognitive impairment as per MMSE Severe depression according to the Beck questionnaire
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of pain intensity. Timepoint: Before surgery, on day 14, and three months post-surgery. Method of measurement: visual analogue Scale (VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Rezapour
Mazandaran University of Medical Sciences
Outcome results
None listed