migraine. Migraine
Conditions
Interventions
Intervention group: Helicobacter Pylori eradication regimen (3-drug regimen) with amoxicillin 1000 mg every 12 hours, clarithromycin 500 mg every 12 hours, and omeprazole 20 mg every 12 hours for 2 we
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Migraine without aura according to IHS diagnostic criteria Helicobacter Pylori fecal antigen positive test Lack of control of migraine attacks despite the classic treatment of migraine (the MIDAS score is mostly equal to 6, which is performed by a neurologist)
Exclusion criteria
Exclusion criteria: Inability to cooperate Consumption of alcohol, smoking and contraceptive drugs Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity score of migraine attacks in MIDAS questionnaire. Timepoint: The beginning of the study (before the start of the intervention), 3 months after completing the Helicobacter Pylori eradication regimen. Method of measurement: Migraine disability assessment questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| The prevalence of Helicobacter Pylori in patients with migraine without aura. Timepoint: The beginning of the study (before the start of the intervention). Method of measurement: Helicobacter Pylori fecal antigen test.;Eradication rate of Helicobacter Pylori in patients with migraine without aura after completion of treatment. Timepoint: 4 weeks after the completion of the Helicobacter Pylori eradication regimen. Method of measurement: Helicobacter Pylori fecal antigen test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Alimardani
Mashhad University of Medical Sciences
Outcome results
None listed