Condition 1: Degenerative spinal conditions such as spinal stenosis. Condition 2: Spondylolisthesis. Condition 3: Degenerative scoliosis. Spinal stenosis, lumbar region Spondylolisthesis, multiple sites in spine Scoliosis, unspecified
Conditions
Interventions
Intervention 1: Intervention group one: will receive ketamine at a dose of 0.5 mg/kg as a bolus before the incision, followed by an infusion at a rate of 0.3 mg/kg/h. Intervention 2: Intervention grou
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients undergoing single-level or multi-level elective lumbar fusion Non-emergency patients seeking treatment for the repair and management of degenerative spinal conditions (such as spinal stenosis with degenerative spondylitis, degenerative scoliosis, or spondylolisthesis) Age range: 18-65 years
Exclusion criteria
Exclusion criteria: Trauma patients Opioid use prior to surgery History of opioid dependency BMI>35 Uncontrolled and unstable ischemic heart disease Increased intracranial pressure (ICP) or intraocular pressure (IOP) Breastfeeding Specific sensitivity to ketamine, propofol, and remifentanil Severe psychiatric and psychotic disorders Inability to work with Visual Analog Scale (VAS) for pain assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: The pain intensity will be assessed and evaluated at the beginning of the patient's presence in the Post-Anesthesia Care Unit (PACU), one hour after the end of surgery upon discharge from the PACU, as well as at 2, 4, 6, 12, and 24 hours after the operation. Method of measurement: Visual Analogue Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mahyar Hashemian
Tehran University of Medical Sciences
Outcome results
None listed