Determining the effect of emotion regulation training and metabolic profile in people with a history of opioid use

Determining the effect of emotion regulation training in improving working memory, response inhibition, cognitive flexibility and metabolic profile in people with a history of opioid use under the methadone maintenance treatment.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241009063311N1

Enrollment

Registered

2026-03-15

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid dependence (undergoing methadone maintenance treatment).. Opioid dependence, uncomplicated

Interventions

Intervention 1: Intervention group: Emotion regulation training will be conducted based on the Gross (2002) protocol. This intervention consists of eight 45-minute group sessions over 8 weeks (one ses

Eligibility

Sex/Gender

Male

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: History of using opium and its derivatives History of six months or more under maintenance treatment with methadone Providing a negative morphine test Having informed consent to participate in the research Being at least 18 and at most 50 years old At least third middle school education

Exclusion criteria

Exclusion criteria: Suffering from psychotic disorders and delusions Illiteracy Female gender History of using other substances such as methamphetamine, hashish, etc. Suffering from personality disorders Suffering from bipolar disorder

Design outcomes

Primary

Measure	Time frame
Difficulties in Emotion Regulation. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Difficulties in Emotion Regulation Scale (DERS).;Working memory. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Wechsler Working Memory Test.;Response inhibition. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Go/No-Go Task for assessing response inhibition.;Cognitive flexibility. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Wisconsin Card Sorting Test for assessing cognitive flexibility.;Metabolic profile. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Nuclear Magnetic Resonance Spectroscopy.	—

Measure

Time frame

Difficulties in Emotion Regulation. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Difficulties in Emotion Regulation Scale (DERS).;Working memory. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Wechsler Working Memory Test.;Response inhibition. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Go/No-Go Task for assessing response inhibition.;Cognitive flexibility. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Wisconsin Card Sorting Test for assessing cognitive flexibility.;Metabolic profile. Timepoint: Before the start of the intervention and at the end of the intervention sessions. Method of measurement: Nuclear Magnetic Resonance Spectroscopy.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Gharagoozloo

Zanjan University of Medical Sciences

Fatemeh.gh1982@gmail.com+98 21 3385 4166

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026