Osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Control group: The group receiving hyaluronic acid (Viscor ampoule, Nitka) via intra-articular injection of hyaluronic acid in the knee at the beginning and 6 months after the start of
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Having mild to moderate osteoarthritis of the knee according to the American College of Rheumatology (ACR) criteria (pain in the knee and at least three of the following: age> 50 years, stiffness< 30 minutes, crepitus, bone tenderness, bone enlargement, and no presence of palpable heat) Having Kellgren-Lawrence radiological criteria grade 1, 2 and 3 Obtaining a score of at least 5 from the VAS pain visual analog scale Lack of response to previous conservative treatments
Exclusion criteria
Exclusion criteria: Patients with rheumatological problems such as rheumatoid arthritis, history of knee joint surgery, history of lower limb bone fracture with knee joint surface involvement Previous diagnosis of polyarthritis Severe extra-articular mechanical deformity (>15 degrees of varus/15 degrees of valgus) Severe osteoarthritis of the knee (radiology score 4),5. People with a history of kidney and liver disease according to the patient's statements People taking anticoagulant drugs People with neuropathy and sensory disorders and skin disease in the knee area Chronic treatment with suppressive drugs, treatment with corticosteroids and treatment with PRP in the last 3 months, non-steroidal anti-inflammatory drugs in the last 15 days OA Bilateral knee osteoarthritis that requires treatment in both knees10. Poorly controlled diabetes, blood dyscrasia, and allergy to HA or bird proteins Existence of inflammatory symptoms and effusion in the joint
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in average pain intensity score. Timepoint: 1, 3, 6, and 12 months after the start of the intervention. Method of measurement: Visual Analogue Scale (VAS).;Changes in the mean functional disability score. Timepoint: 1, 3, 6, and 12 months after the start of the intervention. Method of measurement: The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Lequesne Indices. | — |
Secondary
| Measure | Time frame |
|---|---|
| The amount and severity of adverse events. Timepoint: 1, 3, 6, and 12 months after the start of the intervention. Method of measurement: The average quality of life score obtained from the SF-36 quality of life questionnaire.;The level of satisfaction with the received intervention. Timepoint: 1, 3, 6, and 12 months after the start of the intervention. Method of measurement: The average quality of life score obtained from the SF-36 quality of life questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbolfazl Barzegari
Tabriz University of Medical Sciences
Outcome results
None listed