Condition 1: Burn of second degree. Condition 2: Burn of second degree of shoulder and upper limb, except wrist and hand. Condition 3: Burn of second degree of wrist and hand. Condition 4: Burn of second degree of hip and lower limb, except ankle and foot. Condition 5: Burn of second degree of ankle and foot. Burn of second degree of trunk Burn of second degree of shoulder and upper limb, except wrist and hand Burn of second degree of wrist and hand Burn of second degree of lower limb, excep
Conditions
Interventions
Intervention 1: Intervention group: In addition to standard treatment protocol, they will received cold atmospheric plasma with argon gas, and standard treatment (SC). Intervention 2: Control group:
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with second-degree thermal burns with a total body surface area burn extent Less than 5 percent The burn must have occurred less than or within 24 hours before starting treatment The patients have age between16-65 years Having informed consent
Exclusion criteria
Exclusion criteria: Non-thermal burn Third degree burn Having systemic symptoms Lack of informed consent The healing time may take more than 3 weeks Patients with underlying diseases such as epilepsy, diabetes, immunodeficiency disease, electrical and chemical burns, known allergy and sensitivity to AEO or SSD. Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound healing. Timepoint: On 1, 7, 13, 20, and 30 days after treatment. Method of measurement: Digital photography.;Would healing time. Timepoint: On 1, 7, 13, 20, and 30 days after treatment. Method of measurement: Calendar.;The amount of pain. Timepoint: On 1, 7, 13, 20, and 30 days after treatment. Method of measurement: Observation of the patient during examination, questionnaire visual analogue scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Scar formation. Timepoint: A questionnaire will be given on days 1, 7, 13, 20, and 30 after treatment, and gene expression evaluation will be performed before the intervention and after wound healing. Method of measurement: The Patient and Observer Scar Assessment Scale questionnaire, Transforming growth factor beta, and Vascular endothelial growth factor gene expression to evaluate scar formation.;Infection. Timepoint: On days 1, 7, 13, 20 and 30 after treatment. Method of measurement: Observation of the patient during the examination. If signs of infection are observed, a sample will be taken for microbial culture, and the type of infectious agent and the number of microbial colonies will be determined. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZohreh Hajheidari
Mazandaran University of Medical Sciences
Outcome results
None listed