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Investigating the effects of Dextromethorphan and Acetaminophen on the control of pain caused by diabetes

Investigating the efficacy of Dextromethorphan in comparison with Acetaminophen on the management of neuropathic pain in diabetic patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241006063272N1
Enrollment
96
Registered
2024-10-13
Start date
2024-07-15
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 Diabetes. Type 2 Diabetes mellitus

Interventions

Intervention 1: The first intervention group with 15 mg dextromethorphan tablets twice at night (30 mg in total) for 3 months. Intervention 2: The second intervention group of acetaminophen 500 mg tab

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with type 2 diabetes who have neuropathy.. The number of years the patient has diabetes Patients with controlled diabetes and stable sugar and Hemoglobin A1C At least 30 days before the start of sampling, the patient has used fixed anti diabetic drugs. Patients who are willing and able to follow the treatment protocol during the study. Male or female 18 to 75 years old Minimum pain score of 40 mm or more than 100 mm with visual analogue scale

Exclusion criteria

Exclusion criteria: Having Megaloblastic anemia Vitamin B12 deficiency HIV infection Breastfeeding or pregnancy Hereditary neuropathies Heavy metal neuropathy Uremia Type 1 Diabetes The duration of diabetes is less than three years Having liver disorders

Design outcomes

Primary

MeasureTime frame
Pain score. Timepoint: 3 months after taking the drug. Method of measurement: With Visual Analogue Scale.

Secondary

MeasureTime frame
Paresthesia score. Timepoint: Three months after taking the drug. Method of measurement: With Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Akbar Nasiri

Oroumia University of Medical Sciences

nasiriali7@gmail.com+98 44 3223 1930

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026