Condition 1: Bronchopulmonary dysplasia. Condition 2: Respiratory distress syndrome. Condition 3: Apnea Of Prematurity. Bronchopulmonary dysplasia originating in the perinatal period Respiratory distress of newborn Other apnea of newborn
Conditions
Interventions
Intervention 1: Intervention group: Receiving a high dose of caffeine citrate as a 40 mg/kg loading dose, with 20 mg/kg initially, then 10 mg/kg 12 hours and 24 hours after the initial dose, and a mai
loading dose 20 mg/kg and 10 mg/kg for maintenance dose.
Sponsors
Birjand University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to No maximum
Inclusion criteria
Inclusion criteria: All newborn neonates with gestational age of less than 32 weeks admitted in the first 24 hours of birth Having informed written consent of the legal parents of premature neonates to enter the study
Exclusion criteria
Exclusion criteria: opium withdrawal syndrome respiratory failure( No requirement of fractional concentration of oxygen in inspired gas 80% or more at least for 6 hours and or no requirement of more than of two positive inotropic agents and without considering Hydrocortison significant brain injuries(Intraventricular hemorrhage with grade 3 and 4) congenital anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need O2 therapy. Timepoint: During Hospitalization. Method of measurement: days of O2 therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Prematurity complications. Timepoint: during hospitalization. Method of measurement: seizure, intracranial hemorrhage, and Patent ductus arteriosus, necrotising enterocolitis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Amin Mollazadeh
Birjand University of Medical Sciences
Outcome results
None listed