Venous thromboembolism. I80.1: Phlebitis and thrombophlebitis of femoral vein
Conditions
Interventions
Intervention 1: Intervention group 1: Patients admitted to the ICU received 5000 units of non-fractionated heparin subcutaneously every 12 hours
the infusion began on the day of study entry and continued for at least 7 days or until discharge. Intervention 2: Second intervention group: Patients received unfractionated heparin with an initial b
duration similar to the first group.
Sponsors
Bandare-abbas University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Individuals aged 18 to 70 years Use of vasopressors Use of a central venous catheter Patients with platelet transfusions Patients with previous Venous Thromboembolism
Exclusion criteria
Exclusion criteria: Patients who develop heparin-induced thrombocytopenia (HIT) after starting treatment. Patients who experience bleeding at the surgical site or intracerebral bleeding (including epidural hematoma, subdural hematoma, intracerebral hemorrhage, and hemorrhagic stroke). Patients who require surgery for any reason; in these cases, heparin is discontinued 6 hours before surgery and the patient is excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of venous thromboembolism during intensive care unit hospitalization, based on clinical diagnosis and confirmed by imaging modalities (Doppler ultrasonography or computed tomography angiography). Timepoint: From admission to discharge from the intensive care unit. Method of measurement: Clinical assessment by the attending physician with diagnostic confirmation using Doppler ultrasonography or computed tomography angiography.;Changes in platelet count. Timepoint: Baseline (day 0), day 3, and day 7 of intensive care unit hospitalization. Method of measurement: Laboratory measurement of platelet count using a venous blood sample; unit: ×1000/µL.;Changes in prothrombin time. Timepoint: Baseline (day 0), day 3, and day 7 of intensive care unit hospitalization. Method of measurement: Laboratory measurement of prothrombin time using a venous blood sample; unit: seconds.;Changes in international normalized ratio. Timepoint: Baseline (day 0), day 3, and day 7 of intensive care unit hospitalization. Method of measurement: Laboratory measurement of international normalized ratio using a venous blood sample; unitless.;Changes in activated partial thromboplastin time. Timepoint: Baseline (day 0), day 3, and day 7 of intensive care unit hospitalization. Method of measurement: Laboratory measurement of activated partial thromboplastin time using a venous blood sample; unit: seconds. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of major bleeding during intensive care unit hospitalization. Timepoint: From admission to discharge from the intensive care unit. Method of measurement: Clinical evaluation by the attending physician and review of medical records based on standard criteria for major bleeding (including a decrease in hemoglobin level, need for blood transfusion, or bleeding at critical sites).;Occurrence of thrombocytopenia. Timepoint: Baseline (day 0), day 3, and day 7 of intensive care unit hospitalization. Method of measurement: Laboratory measurement of platelet count using a venous blood sample; thrombocytopenia defined as a platelet count below the institutional reference range.;Length of intensive care unit stay. Timepoint: At discharge from the intensive care unit. Method of measurement: Calculation of the duration of intensive care unit hospitalization based on medical records; unit: days.;Mortality. Timepoint: From admission to discharge from the intensive care unit. Method of measurement: Assessment of survival status through medical records during intensive care unit hospitalization.;Difference in lower limb circumference. Timepoint: Baseline (day 0), day 3, and day 7 of intensive care unit hospitalization. Method of measurement: Measurement of lower limb circumference using a measuring tape at predefined anatomical landmarks; unit: centimeters. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMajid Vatankhah
Bandare-abbas University of Medical Sciences
Outcome results
None listed