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Comparison of Two Different Doses of Remifentanil on Bleeding and Hemodynamics in Femur Surgery

Comparison of the Effects of Two Different Doses of Remifentanil Infusion on Intraoperative Blood Loss and Hemodynamic Parameters in Patients Undergoing Femur Surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240929063203N3
Enrollment
60
Registered
2025-11-18
Start date
2025-11-22
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery. Encounter for orthopedic aftercare following scoliosis surgery

Interventions

Intervention 1: Intervention group 1: Patients undergoing elective femur surgery under general anesthesia will receive intravenous remifentanil infusion at a dose of 0.25 micrograms per kilogram per m

Sponsors

Bandare-abbas University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Individuals aged 18 to 70 years Candidates for femur surgery Undergoing general anesthesia No use of opioid analgesics before surgery No history of allergy or hypersensitivity to remifentanil or similar drugsRetry

Exclusion criteria

Exclusion criteria: Diagnosis of serious diseases or medical conditions that may affect the study outcomes (such as severe cardiovascular disorders or bradycardia) Allergy or severe hypersensitivity reaction to the medications used in the study. Lack of informed consent or withdrawal of the patient from the study at any stage of the research. If patients require additional morphine during the procedure.

Design outcomes

Primary

MeasureTime frame
Volume of blood loss during femur surgery measured in milliliters. Timepoint: Measured continuously during the surgery from the start of the surgical incision until wound closure. Method of measurement: Measurement of blood volume collected in suction containers and blood-soaked surgical gauzes during surgery.;Systolic blood pressure measured in millimeters of mercury during femur surgery. Timepoint: Measured at baseline (before anesthesia induction) and at 15-minute intervals during surgery. Method of measurement: Non-invasive blood pressure monitoring device (automated sphygmomanometer).;Diastolic blood pressure measured in millimeters of mercury during femur surgery. Timepoint: Measured at baseline (before anesthesia induction) and at 15-minute intervals during surgery. Method of measurement: Non-invasive blood pressure monitoring device (automated sphygmomanometer).;Mean arterial pressure measured in millimeters of mercury during femur surgery. Timepoint: Measured at baseline (before anesthesia induction) and at 15-minute intervals during surgery. Method of measurement: Calculated automatically by non-invasive blood pressure monitoring device using the formula: MAP = DBP + 1/3(SBP - DBP).;Heart rate measured in beats per minute during femur surgery. Timepoint: Measured at baseline (before anesthesia induction) and at 15-minute intervals during surgery. Method of measurement: Electrocardiogram (ECG) monitoring device and pulse oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrdad Malekshoar

Bandare-abbas University of Medical Sciences

mdmalekshoar@yahoo.com?+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026