Effect of famotidine on vagal inflammatory reflex

Evaluation of the effect of famotidine in activating the vagus inflammatory reflex in patients undergoing open heart surgery: a randomized controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240927063180N1

Enrollment

Registered

2024-12-26

Start date

2024-12-25

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group: Patients are randomly prescribed famotidine 40 mg at 8 pm the day before surgery and then continue to take famotidine 40 mg daily (morning of surgery) until transfe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Candidate patients for open heart surgery in Baqiyatallah Hospital Patients with informed consent to enter the plan

Exclusion criteria

Exclusion criteria: Patients allergic to famotidine Patients without informed consent Patients with a history of severe peptic ulcer and treated with PPI

Design outcomes

Primary

Measure	Time frame
Tumor necrosis factor alpha. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;Interleukin-6. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;Interleukin-8. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;White blood cells. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Numerical counting.;Lactic acid. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Biochemical kit.;C-reactive protein. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;Lactate dehydrogenase. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Biochemical kit.;Creatine phosphokinase. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Biochemical kit.	—

Measure

Time frame

Tumor necrosis factor alpha. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;Interleukin-6. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;Interleukin-8. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;White blood cells. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Numerical counting.;Lactic acid. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Biochemical kit.;C-reactive protein. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: ELISA kit.;Lactate dehydrogenase. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Biochemical kit.;Creatine phosphokinase. Timepoint: 12 hours before surgery and after surgery in the ICU, 24 hours after surgery, and then on the 48th and 4th day after surgery in both groups (5 samples per patient). Method of measurement: Biochemical kit.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahid Daman pak moghadam

Bagheiat-allah University of Medical Sciences

vahid65037@gmail.com+98 21 8805 0435

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026