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Comparison the Effectiveness of Atomoxetine and NAC in reducing cravings in patient with Methamphetamine abuse disorder

Comparison the Effectiveness of Atomoxetine and NAC in reducing cravings in patient with Methamphetamine abuse disorder

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240924063151N1
Enrollment
116
Registered
2024-11-03
Start date
2024-11-05
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mehtamphetamin Abuse Disorder. Other stimulant abuse with stimulant-induced psychotic disorder

Interventions

Methamphetamine users treated with atomoxetine, including 56 people who referred to the addiction clinic of Amirkabir Hospital with a history of methamphetamine use who intend to be treated. If these
The second group 56 Methamphetamin abuser treated with NAC, this medicine starts with a dose of 600 mg per day in the form of a 600 mg NAC effervescent tablet made by Hakim Pharmaceutical Company, o

Sponsors

Arak University of Medical Sciences
Lead Sponsor
Arak University of Medical Sciences
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 50 years; Suffering from amphetamine abuse based on the diagnosis of a psychiatric specialist; No history of allergy to Atomoxetine or NAC Absence of contraindications for atomoxetine or NAC (contraindications for NAC include a history of allergy and asthma, and contraindications for atomoxetine include a history of allergy, angle-closure glaucoma, advanced cardiovascular problems, pheochromocytoma, and use ofMAo-inhibiting drugs in the last two weeks ) Informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Prescribing medications that interact with atomoxetine such as MAO inh Pregnancy and Breastfeeding Suffering from malignant hypertension (higher than 110/180)- Suffering from chronic kidney and liver disease Suffering from serious neurological and mental disorders based on a DSM, including schizophrenia and schizoaffective disorder

Design outcomes

Primary

MeasureTime frame
Craving to Methamphetamine. Timepoint: Assessment of craving for Methamphetamine in 0, 2, 4, 6, 8 weeks from beginning of trial. Method of measurement: Questionnaire to measure the temptation to use drugs after quitting (Federdi, Barerfan and Ziyai; 2008).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarideh Ranjbaran

Arak University of Medical Sciences

paramed@arakmu.ac.ir+98 86 3417 3526

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026