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Evaluating effectiveness of an antifungal gel in patients with tinea corporis

Evaluating the effectiveness of a silicone gel containing antifungal compounds in patients with tinea corporis

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240923063136N3
Enrollment
100
Registered
2025-04-25
Start date
2025-10-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin fungal infection. Tinea corporis

Interventions

Intervention 1: Intervention group 1 will receive silicone gel containing two antifungal compounds, terbinafine and thymol. The amount of terbinafine is 1% and the amount of thymol is 3%. This is the

Sponsors

Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients who have been ill for fewer than 7 days will be included in the study. All patients who are positive for dermatophyte filaments on 10% KOH mount and have less than 20% of their body surface area involved will be included in the study. No other skin disease should be reported. Erythema, scaling rash, and itching should be at least 2 numbers.

Exclusion criteria

Exclusion criteria: Patients with diabetes, HIV, diseases and immune system problems will not be included in the study. Patients with a history of hypersensitivity reactions to terbinafine were not included in the study. Individuals who are using topical or systemic corticosteroids, antibiotics, or antifungal treatments, or have used them within four weeks prior to the start of the study, will not be included in the study. Pregnant, lactating women, or those planning to become pregnant were not included in the study.

Design outcomes

Primary

MeasureTime frame
Symptoms of fungal infection. Timepoint: Before intervention (day 0), and after intervention (day 15). Method of measurement: Potassium hydroxide (KOH) preparation test.

Secondary

MeasureTime frame
Erythema at the site of infection. Timepoint: Before intervention (day 0), and after intervention (day 15). Method of measurement: Visual assessment.;Scaling at the site of infection. Timepoint: Before intervention (day 0), and after intervention (day 15). Method of measurement: Visual assessment.;Burning/itching sensation at the site of infection. Timepoint: Before intervention (day 0), and after intervention (day 15). Method of measurement: visual analogue scale (VAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactCyrus Jalili

Kermanshah University of Medical Sciences

cjalili@kums.ac.ir+98 38 3835 8943

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026