Leiomyoma of uterus. Leiomyoma of uterus
Conditions
Interventions
Intervention 1: Intervention group: 400 micrograms (2 tablets of 200 micrograms of misoprostol, Pfizer company) sublingually one hour before surgery, single dose. Intervention 2: Control group: Placeb
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 39 Years
Inclusion criteria
Inclusion criteria: Age between 20 and 39 years. A maximum of 5 uterine fibroids. Maximum diameter of the largest fibroid is 6 cm. All fibroids classified as intramural or subserosal by ultrasound uterine size less than 24 weeks of pregnancy on bimanual examination.
Exclusion criteria
Exclusion criteria: history of previous pelvic or abdominal surgery (laparotomy) history of endometriosis sensitivity to misoprostol hypertension cardiovascular or pulmonary diseases bleeding or coagulation disorders, anemia (Hb 30 kg/m²).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical estimation of the amount of blood lost in CC. Timepoint: Before surgery, one hour after surgery, and 24 hours after surgery. Method of measurement: Surgical towels are weighed before and after the procedure using a scale with an accuracy of 1 gram, and the weight difference is calculated. One gram is considered equivalent to 1 milliliter of blood. The weight of empty suction bottles will be subtracted from that of filled bottles. Additionally, we will subtract the estimated blood collected on the ground as well as the volume of fluids used for irrigation from this amount. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in hemoglobin before and after surgery. Timepoint: One and 24 hours after surgery. Method of measurement: Measurment in blood sample.;Difference in hematocrite before and after surgery. Timepoint: One and 24 hours after surgery. Method of measurement: Measurment in blood sample.;Duration of hospitalization. Timepoint: Discharge day. Method of measurement: Days.;Fever after surgery. Timepoint: One and 24 hours after surgery. Method of measurement: thermometer.;Duration of operation. Timepoint: After surgery. Method of measurement: Minutes.;Need for blood transfusion during operation. Timepoint: after surgery. Method of measurement: Surgery report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomayyeh Moradpanah
Tehran University of Medical Sciences
Outcome results
None listed