Infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: The group receiving the probiotic in the form of Lactofem capsules, a product of the knowledge-based company, Zist Takhmir. The contents of the Lactofem capsule inc
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Patients who have frozen embryos and are scheduled for embryo transfer A maximum of two unsuccessful IVF cycles The patient must provide informed consent and fully understand the details, potential risks, and benefits of participating in the study
Exclusion criteria
Exclusion criteria: Body mass index above 35 Thrombophlebitis Inherited thromboembolic disorders Cerebrovascular disease Coronary artery disease or a history of these diseases Significant liver dysfunction Hepatitis Liver cancer Migraine headaches with aura Diabetes with vascular complications Suspected or known breast cancer Cigarette smoking with age over 35 years Severely elevated cholesterol or triglyceride levels (above 240 and 200 mg/dl, respectively) Uncontrolled hypertension History of peripartum cardiomyopathy Lactofem contraindications Estradiol contraindications Consumption of immunosuppressive drugs History of food or drug allergies AIDS Immune system deficiency Signs of severe infection such as nausea, vomiting, severe abdominal pain, and bloody diarrhea Treatment with chemotherapy drugs Heart valve-related diseases History of ulcerative colitis History of irritable bowel syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy success. Timepoint: after 24 days, after 34 days from probiotic or placebo started. Method of measurement: b-hCG test, ultrasound for gestational sac visualization, and ultrasound for fetal heart activity visualization. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Ghamsari
Kashan University of Medical Sciences
Outcome results
None listed