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Evaluation of therapeutic effect of olive leaf on cutaneous leishmaniasis in humans

Evaluation of therapeutic effect of olive leaf extract with Glucantime® on cutaneous leishmaniasis in humans: A clinical trial study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240918063090N1
Enrollment
69
Registered
2024-11-22
Start date
2024-09-26
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

B55.1Cutaneous leishmaniasis. Cutaneous leishmaniasis

Interventions

Intervention 1: Group A: They receive Glucantime medicine once a week for up to 4 weeks (one month) and at the same time, 30 mg/kg ointment is used twice a day for one month by trained therapists. Int

Sponsors

Khorramabad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients who refer to the standard treatment centers of Salak in Ilam province and the disease of cutaneous leishmaniasis is confirmed by microscopic and molecular diagnosis methods At the time of entering the study in the age range between 18 and 85 years The number of lesions less than 5 per patient and the wound size with a maximum diameter of five centimeters, the duration of lesions more than four months and patients who have not received anti-leishmania drugs in the last four months. The wounds are not purulent, atypical, in sensitive parts of the body, such as the face and joints, and they do not have a history of cutaneous leishmaniasis. The patient must express her/his consent to participate in the treatment program and be willing to participate in it The patient should be referred by the attending physician to the Salak treatment center in the city to receive medical services. A patient for whom anti-leishmania treatment has not been started before

Exclusion criteria

Exclusion criteria: The patient's unwillingness to continue to cooperate in the research Patients who do not participate in more than one treatment session. Necessary travel Death of the patient or migration from the city Pregnant and lactating women concomitant use of medication to treat psoriasis or use of immunosuppressant drugs during the six months leading to the patient's entry into the study.

Design outcomes

Primary

MeasureTime frame
In the present study, the main outcomes are: 1- Changes in wound size after the start of treatment. Timepoint: The diameter of the patients' wounds is measured with a caliper at 0, 7, 14, 21, and 28 days after the therapeutic intervention. Method of measurement: Weekly during treatment to measure each lesion in 2 dimensions (length and width) once a week for 1 month with a simple 15 cm caliper.;2- Duration of wound healing in patients with leprosy. Timepoint: The diameter of the patients' wounds is measured with a caliper at 0, 7, 14, 21, and 28 days after the therapeutic intervention. Method of measurement: Weekly during treatment to measure each lesion in 2 dimensions (length and width) once a week for 1 month with a simple 15 cm caliper. The healing of the lesion is defined as the healing of the wound due to the growth of the epithelium on the bare surface of the lesion without recurrence in the 6-month follow-up.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMs. Dr. Farnaz Khairandish

Khoram-Abad University of Medical Sciences

kheirandish??@yahoo.com+98 66 3331 3522

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026