Effect of platelet-rich plasma on chronic endometritis

Evaluation of the effect of platelet-rich plasma on chronic endometritis in patients with recurrent implantation failure

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240917063075N1

Enrollment

Registered

2024-10-28

Start date

2024-10-22

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic endometritis. Chronic inflammatory disease of uterus

Interventions

Intervention group: Women with chronic endometritis with repeated implantation failure.

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Women with chronic endometritis with embryo transfer failure Confirmation of impossibility of fertility using histology and hysteroscopy At least 3 failed embryo transfers without genetic, metabolic or endocrine reasons

Exclusion criteria

Exclusion criteria: Patient's request not to continue participating in the study Presence of other immune diseases and malignancies

Design outcomes

Primary

Measure	Time frame
The thickness of the uterine endometrium. Timepoint: Follicular phase of menstrual cycle after platelet rich plasma infusion. Method of measurement: Hysteroscopy and sampling and sample analysis by a pathologist.;Changes in uterine tissue. Timepoint: Follicular phase of menstrual cycle after platelet rich plasma infusion. Method of measurement: Hysteroscopy and sampling and sample analysis by a pathologist.;Successful pregnancy. Timepoint: Week 5. Method of measurement: Based on blood beta hCG titer.	—

Measure

Time frame

The thickness of the uterine endometrium. Timepoint: Follicular phase of menstrual cycle after platelet rich plasma infusion. Method of measurement: Hysteroscopy and sampling and sample analysis by a pathologist.;Changes in uterine tissue. Timepoint: Follicular phase of menstrual cycle after platelet rich plasma infusion. Method of measurement: Hysteroscopy and sampling and sample analysis by a pathologist.;Successful pregnancy. Timepoint: Week 5. Method of measurement: Based on blood beta hCG titer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Ayar

Shahre-kord University of Medical Sciences

maryamayar2769@gmail.com+98 38 3225 2416

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026