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The effect of papaverine and intraoperative hydro dissection in varicocelectomy surgery

Technical comparison of inguinal varicocelectomy open using two methods of topical papaverine injection and intraoperative hydro dissection on surgical complications and sperm parameters in infertile men referred

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240916063070N1
Enrollment
114
Registered
2024-09-27
Start date
2024-10-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicocele, papaverine, hydro dissection. Scrotal varices

Interventions

Intervention 1: Intervention group: In the first group of patients, using local injection of papaverine using an insulin syringe, one ampule of papaverine 40mg/ml for each patient is completely poured

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: primary varicocele unilateral on the left side small testis, where the difference of 10% of the testis volume or more with the testis on the healthy side was considered as a small testis as a control due to infertility and decreased sperm count Semen analysis has been referred

Exclusion criteria

Exclusion criteria: simultaneous presence of hydrocele simultaneous presence of hernia sensitivity to papaverine

Design outcomes

Primary

MeasureTime frame
Examining the preservation of the artery and its pulse using Doppler ultrasound. Timepoint: 3 months after intervention. Method of measurement: Doppler ultrasound device.;Examining the difference in the size of the testicles using Doppler ultrasound and the formula (length*width*height*52.) and physical examination. Timepoint: 3 months after intervention. Method of measurement: Doppler ultrasound device, physical examination.;The level of difficulty of the surgery will be evaluated based on the surgeon's evaluation scale regarding the difficulty in diagnosing and preserving the arteries with the scale of the difficulty of the surgery (difficult = 3, moderate = 2, easy = 1). Timepoint: During surgery. Method of measurement: Assigned numbers depending on the degree of difficulty.;Spermogram parameters will be compared using semen analysis before and three months after the operation. Timepoint: 3months after intervention. Method of measurement: Semen analysis.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactServeh Mohammadi

Hamedan University of Medical Sciences

serveh.mohamadi76@gmail.com+98 44 4222 7846

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026