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Anti-inflammatory and Soothing effect of Koma plant on Rheumatoid arthritis.

Investigating the anti-inflammatory and soothing effects of the hydroalcoholic extracts of Koma (Frula persica) and Qaraqat (Vaccinium arctostaphylus) plants in comparison with corticosteroid therapy in patients with Rheumatoid arthritis.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240916063066N1
Enrollment
88
Registered
2024-10-09
Start date
2025-06-15
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis. Rheumatoid arthritis with rheumatoid factor

Interventions

Intervention 1: Intervention group 1:The first group is group A, in this group, the extract of the native plant of Iran, koma (Freula persica), which is obtained from its root and stem, and the hydroa

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients Suffering from Joint Pain and Rheumatoid arthritis Age 18 to 80 Years Old Body Weight 60 to 150 kg Gender Male & Female Daily Activity Rate from 0 to 24 Hours

Exclusion criteria

Exclusion criteria: Pregnant and Nursing mothers Taking Confounding Medications such as Corticosteroids and NSAIDs Confounding Surgical Records Based on Orthopedic, Brain, or any Type of Surgery That Disrupts the Immune and Motor Systems. Suffering from diseases of the immune and motor systems except Rheumatoid arthritis Confounding Occupations Based on the Place, Manner and Hours of Activity That are Effective on The Improvement or Non-Improvement of the Disease.

Design outcomes

Primary

MeasureTime frame
Reduction of Rheumatoid factor in Patient Tests after Drug Administration. Timepoint: At the Beginning of the Study, before the Start of the Intervention and then after the end of the Intervention (after 4 Months). Method of measurement: Rheumatoid factor Test by Blood sampling.;Reduction of Antibodies Against cyclic citrullinated peptides (Anti-CCP Antibodies). Timepoint: At the Beginning of the Study, before the Start of the Intervention and then after the end of the Intervention (after 4 Months). Method of measurement: Anti cyclic citrullinated peptide(Anti-CCP)Test by Blood sampling.;Pain reduction. Timepoint: At the Beginning of the Study (before the start of the Intervention) and once a Week until the end of the Intervention and Completion of the Treatment. Method of measurement: Clinical examinations; ?Questionnaires.;Inflammation reduction. Timepoint: At the Beginning of the Study (before the start of the Intervention) and once a Month until the end of the Intervention and Completion of the Treatment. Method of measurement: Clinical examinations; C-reactive protein measurement by blood sampling (CRP).

Secondary

MeasureTime frame
Effective on other Joint pains. Timepoint: At the Beginning of the Study (before the start of the Intervention) and once a Week until the end of the Intervention and Completion of the Treatment. Method of measurement: Clinical examinations; Questionnaires.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArmin Deyhim

Islamic Azad University

deyhim34@gmail.com+98 21 4482 3811

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026