Amyotrophic lateral sclerosis. Motor neuron disease
Conditions
Interventions
Intervention 1: Intervention group: Near-infrared (NIR) laser therapy by velight device a Canadian-made with a wavelength of 810 nm and a pulse of 10 Hz, for a duration of 20 minutes, will be transcr
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: The age range is 25 to 60 years Have MND nerve band Have ALS_FRS score > 24 Not having a serious medical illness other than amyotrophic lateral sclerosis (ALS) No drug addiction Do not have a major psychiatric or neurological disorder
Exclusion criteria
Exclusion criteria: Patients need special care for respiratory failure Have heart disease Have a metabolic disorder Have a history of moderate or severe brain damage or stroke Have a history of cardiac arrhythmia Have kidney disease, such as chronic kidney failure Failure to participate in 3 sessions will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of transcranial and intranasal low power laser in reducing inflammation. Timepoint: In four stages (before the intervention and in weeks 2, 4, 6 of the study). Method of measurement: Real time PCR.;Effectiveness of transcranial and intranasal low power laser in reducing oxidant effects. Timepoint: In four stages (before the intervention and in weeks 2, 4, 6 of the study). Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: The beginning of the study and after the completion of the intervention. Method of measurement: Quality of life questionnaire SF-36 Questionnaire.;Sleep quality. Timepoint: It will be measured in two stages, at the beginning of the study and after the end of the intervention. Method of measurement: The Pittsburgh Sleep Quality Index (PSQI).;The pain. Timepoint: It will be measured in two stages (at the beginning of the study and after the end of the intervention). Method of measurement: Questionnaire.;Measurement of motor performance improvement. Timepoint: In three stages (beginning of the study and after the completion of the intervention and three months after the intervention). Method of measurement: EMG- NCS.;Pseudobulbar effects. Timepoint: It will be measured in two phases, at the beginning of the study and after the end of the intervention. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHoma Talebi
Iran University of Medical Sciences
Outcome results
None listed