Comparison of the Effects of Two Types of Blood Flow (Pulsatile and Non-Pulsatile) on Clinical Outcomes After Coronary Bypass Surgery.

Comparison of the effect of pulsatile and non-pulsatile flow on clinical outcomes after coronary artery bypass surgery.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240916063056N1

Enrollment

Registered

2024-10-28

Start date

2024-12-01

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Grafting. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group(A): Both groups utilize the same anesthesia method following standard protocols, surgical techniques, and team. This study involves the removal of the left internal

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Adult patients with ASA grade II or III (American Society of Anesthesiology classification) Adult patients between 40 and 70 years old Adult patients who are candidates for CABG

Exclusion criteria

Exclusion criteria: Positive history of asthma, bronchitis, emphysema, sepsis, kidney, liver, recent heart or brain stroke and autoimmune disease. Decrease the level of consciousness before the operation. Heavy smokers. CPB time should be more than 120 minutes. Positive history of chemotherapy or radiotherapy.

Design outcomes

Primary

Measure	Time frame
Vasoactive-Inotropic Score (VIS). Timepoint: The first 24 hours after the operation. Method of measurement: Amount of inotropic drugs (epinephrine, nor epinephrine, dopamine).;The duration of mechanical ventilation. Timepoint: From the moment the patient enters the ICU until the discharge from this department. Method of measurement: The number of days the patient is under mechanical ventilation is based on patient Record information.;Length of ICU stay. Timepoint: From the time of the patient's arrival to the date of discharge from the ICU. Method of measurement: According to the number of days of hospitalization of the patient in the ICU department.;Urinary output after surgery. Timepoint: The first 24 hours after the operation. Method of measurement: Based on patient Record information.;The need to use a pacemaker. Timepoint: Length of ICU stay. Method of measurement: Based on patient Record information.	—

Measure

Time frame

Vasoactive-Inotropic Score (VIS). Timepoint: The first 24 hours after the operation. Method of measurement: Amount of inotropic drugs (epinephrine, nor epinephrine, dopamine).;The duration of mechanical ventilation. Timepoint: From the moment the patient enters the ICU until the discharge from this department. Method of measurement: The number of days the patient is under mechanical ventilation is based on patient Record information.;Length of ICU stay. Timepoint: From the time of the patient's arrival to the date of discharge from the ICU. Method of measurement: According to the number of days of hospitalization of the patient in the ICU department.;Urinary output after surgery. Timepoint: The first 24 hours after the operation. Method of measurement: Based on patient Record information.;The need to use a pacemaker. Timepoint: Length of ICU stay. Method of measurement: Based on patient Record information.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKianoush Rezaei Far

Shiraz University of Medical Sciences

kianrf74@gmail.com+98 71 1231 8072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026