The Effectiveness of Transcranial Direct Current Stimulation (tDCS) on the Treatment Outcome of Generalized Anxiety Disorder

Investigating the effect of transcranial direct current stimulation on the intensity of anxiety, worry, uncertainty intolerance, attention bias and occupational and social performance of patients with generalized anxiety disorder.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240914063034N1

Enrollment

Registered

2025-01-28

Start date

2025-04-05

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized Anxiety Disorder. Generalized anxiety disorder

Interventions

Intervention 1: Intervention Group: Transcranial Direct Current Stimulation (tDCS) using the NeuroStim2 device, manufactured by Medinateb. The current intensity is 2 mA for 20 minutes per session, wit

Eligibility

Sex/Gender

All

Age

20 Years to 39 Years

Inclusion criteria

Inclusion criteria: Participants suffering from generalized anxiety disorder based on the diagnosis of a psychiatrist and a GAD-7 screening score above 10 the dose and type of medication remaining constant during the past month and until the end of the study being right-handed Age range 20 to 39 years

Exclusion criteria

Exclusion criteria: Receiving psychological treatment during the past month - suffering from severe psychiatric and neurological diseases (including epilepsy and convulsive diseases, Alzheimer's disease and other dementias, stroke and other cerebrovascular diseases, brain tumors and other brain lesions, Schizophrenia and other psychotic disorders, bipolar disorder type 1, OCD and substance abuse disorder being pregnant The history of seizure and epilepsy based on case report and self-report The presence of metal objects and implants in the head and body

Design outcomes

Primary

Measure	Time frame
Generalized Anxiety. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: GAD-7.;Worry. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Penn State Worry Questionnaire (PSWQ).;Intolerance of uncertainty. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Intolerance of Uncertainty Scale (IUS).;Attention bias. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Emotional stroop.;Occupational and social functioning. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Work and Social Adjustment Scale (WSAS).	—

Measure

Time frame

Generalized Anxiety. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: GAD-7.;Worry. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Penn State Worry Questionnaire (PSWQ).;Intolerance of uncertainty. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Intolerance of Uncertainty Scale (IUS).;Attention bias. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Emotional stroop.;Occupational and social functioning. Timepoint: The beginning of the study (before the start of the intervention) and the end of the study (after the last session) and 30 days after the end of the intervention. Method of measurement: Work and Social Adjustment Scale (WSAS).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSana AlizadeFardDarAbad

Iran University of Medical Sciences

info@iums.ac.ir+98 21 86701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026