Thy Impact of Low-Dose Ketamine Infusion on Pain Management in Orthopedic Surgeries

Investigation of the Effects of Intraoperative Infusion of Two Low Doses of Ketamine on Pain Intensity Changes Before and After Upper Limb Orthopedic Surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240912063019N1

Enrollment

Registered

2024-10-09

Start date

2024-10-08

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Scapula fracture. Condition 2: Clavicle fracture. Condition 3: Radius and ulna stres fracture. Fracture of scapula Fracture of clavicle Stress fracture, ulna and radius

Interventions

Intervention 1: Intervention group: "Patients receiving ketamine at a dose of 0.5 mg/kg as a bolus IV immediately after induction, followed by an infusion of 0.25 mg/kg/h during the procedure, using t

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ?Patients aged 18 to 65 years ?Patients with ASA classification 1-2 ?Patients scheduled for upper limb orthopedic surgery Patients ?without a history of allergy to the study drugs

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
"Postoperative pain level following upper limb orthopedic surgery based on the Visual Analogue Scale (VAS)". Timepoint: "Determination and comparison of the mean changes in pain intensity at baseline, upon arrival in recovery, 30 and 60 minutes post-operation, and at 2, 4, 6, 12, and 24 hours after admission to the ward among the three groups.". Method of measurement: "Visual Analogue Scale (VAS) questionnaire".	—

Measure

Time frame

"Postoperative pain level following upper limb orthopedic surgery based on the Visual Analogue Scale (VAS)". Timepoint: "Determination and comparison of the mean changes in pain intensity at baseline, upon arrival in recovery, 30 and 60 minutes post-operation, and at 2, 4, 6, 12, and 24 hours after admission to the ward among the three groups.". Method of measurement: "Visual Analogue Scale (VAS) questionnaire".

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Secondary

Measure	Time frame
"The dose of requesting additional analgesics". Timepoint: "From the time of arrival in recovery until 24 hours after admission to the ward". Method of measurement: "Requested additional analgesic dose".;"Mean heart rate at baseline(Before anesthesia)and then every half hour during the procedure". Timepoint: “At baseline(Before anesthesia)and then every half hour during the procedur”. Method of measurement: "cardiac monitoring device".	—

Measure

Time frame

"The dose of requesting additional analgesics". Timepoint: "From the time of arrival in recovery until 24 hours after admission to the ward". Method of measurement: "Requested additional analgesic dose".;"Mean heart rate at baseline(Before anesthesia)and then every half hour during the procedure". Timepoint: “At baseline(Before anesthesia)and then every half hour during the procedur”. Method of measurement: "cardiac monitoring device".

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMoniba Hashemi

Esfahan University of Medical Sciences

monibahashemi@gmail.com00983134395

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026