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"Effect of Antidepressants in Diabetes Control"

Investigating the Effect of Antidepressants Including Citalopram, Escitalopram, and Sertraline on Serum HbA1c Level in Type 2 Diabetic Patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240911063012N1
Enrollment
150
Registered
2025-03-02
Start date
2024-09-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Diabetes mellitus type 2. Condition 2: Depression. diabetes mellitus Major depressive disorder, single episode

Interventions

Intervention 1: First intervention group: Citalopram from Sobhan Darou company is administered with the minimum therapeutic dose of 10 mg and is increased to the maximum dose of 60 mg if necessary unt

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Having Consent to Enter the Study All Type 2 Diabetic Patients with Depression Who Need Single-Drug Treatment with the Opinion of a Psychiatrist and Based on DSM5 Diagnostic Criteria

Exclusion criteria

Exclusion criteria: Lack of Consent to Enter the Study Patients Whose Tests are Not Complete Before Taking the Drugs The Presence of Other Underlying Diseases Besides Diabetes Pregnant Women and Breastfeeding Mothers Patients with very Severe Depression and Severe Diabetes so that they Need to Take More Drugs Presence of Uncontrolled Cardiovascular or Eye Diseases

Design outcomes

Primary

MeasureTime frame
HbA1c level. Timepoint: The measurement of HbA1c level is done at the beginning of the study and 3 months after the initiation of antidepressant medication. Method of measurement: The measurement of HbA1c level is done by the laboratory and as percentage.;Fasting blood sugar. Timepoint: Fasting blood sugar levels are measured at the beginning of the study and 3 months after starting the antidepressant. Method of measurement: The fasting blood sugar level is measured by the laboratory in milligrams per deciliter of blood.

Secondary

MeasureTime frame
Depression level. Timepoint: at the beginning of the study and 3 months after the initiation of antidepressant medication. Method of measurement: beck depression inventory 2.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Taghavi

Islamic Azad University

dr_mahsataghavi@yahoo.com+98 71 3634 1771

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026