Skip to content

Investigating the effectiveness of thiamine in preventing delirium in patients admitted to the ICU

Investigating the effectiveness of thiamine in preventing delirium in patients admitted to the ICU

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240908062983N1
Enrollment
100
Registered
2025-04-05
Start date
2025-03-05
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

delirium. Delirium due to known physiological condition

Interventions

Intervention 1: Intervention group: They receive thiamine tablets 300 mg 3 times a day (from Hakim Pharmaceutical Company) for 5 days. Intervention 2: Control group: they receive placebo tablets three

Sponsors

Shahre-kord University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to No maximum

Inclusion criteria

Inclusion criteria: age > 50 y able to speak Able to provide informed consent Absence of delirium at the time of consent, as defined by the Delirium Rating Scale (ICU-CAM score > 2) Not having a previous history of neuropsychiatric disorders (dementia, Parkinson's, schizophrenia, etc.) No alcohol or drugs Absence of severe renal impairment =30GFR Absence of severe liver impairment The patient should not repent 2= APACHI

Exclusion criteria

Exclusion criteria: delirium at the time of consent, as defined by the Delirium Rating Scale (ICU-CAM score > 2) having a previous history of neuropsychiatric disorders (dementia, Parkinson's, schizophrenia, etc.) alcohol or drugs user severe renal impairment =30GFR severe liver impairment be intube APACHI <2

Design outcomes

Primary

MeasureTime frame
Assessing the delirium score of patients hospitalized in the intensive care unit using the CAM-ICU scoring system, where a score above 2 is considered delirium. Timepoint: 5 days from the start of the medication. Method of measurement: ICU-CAM delirium scoring scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBita Akafi

Shahre-kord University of Medical Sciences

bitaakafi@gmail.com+98 38 3228 2238

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026