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Determining the therapeutic effect of letrozole and dienogest on the amount of bleeding and pain caused by adenomyosis

Determining the therapeutic effect of letrozole and dienogest on the amount of bleeding and pain caused by adenomyosis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240908062973N1
Enrollment
40
Registered
2024-10-15
Start date
2024-11-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adenomyosis. Endometriosis of uterus

Interventions

Intervention 1: Intervention group: 20 randomly selected adenomyosis patients will be treated with letrozole 2.5 mg (Abourihan Pharmaceutical Company) daily orally, for 3 months. Letrozole , which is

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: patients aged 18-40 years who referred to Rasool Akram Hospital with adenomyosis and dysmenorria and heavy mensural bleeding not Taking hormonal drugs containing estrogen or progesterone for three month before no history malignancy in the genital tract or breast not breast feeding for three month before no liver or kidney or blood disease not previous history of deep vein thrombosis or pulmonary emboly not delivery in last 6 months not pregnant

Exclusion criteria

Exclusion criteria: history of malignancy in the genital tract hormon therapy in last three month any systemic disease endometrial ablation with thermal balloon or resectoscope

Design outcomes

Primary

MeasureTime frame
Menstrual bleeding. Timepoint: start of drug- three month later. Method of measurement: each day pad count.;Menstrual pain. Timepoint: start of drug- three month later. Method of measurement: vas score (The Visual Analogue Scale).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamaneh Rokhgireh

Iran University of Medical Sciences

s.rokhgireh@gmail.com+98 21 6435 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026