Studying the effect of Inderal on reducing bleeding during hysterectomy surgery

Evaluation of the effect of oral Inderal on reducing bleeding during abdominal hysterectomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Observational

Source

IRCT

Registry ID

IRCT20240906062960N1

Enrollment

Registered

2025-03-15

Start date

2024-10-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reducing bleeding during abdominal hysterectomy surgery.

Interventions

Intervention 1: Control group: Placebo from the drug manufacturing company. Intervention 2: Intervention group: Inderal tablet (40 mg) 90 minutes before surgery from the pharmaceutical company.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Candidates for hysterectomy

Exclusion criteria

Exclusion criteria: Need for re-surgery Patient withdraws from the study or does not cooperate with further follow-up Raynaud's syndrome, porphyria, renal dysfunction Patients with a history of asthma Patients with low blood pressure Bradycardia

Design outcomes

Primary

Measure	Time frame
The aim is to investigate the effect of oral drug Inderal on reducing bleeding during hysterectomy surgery. Timepoint: . The first group received oral Inderal 20 mg and the second group received placebo 90 minutes before the hysterectomy surgery. Before the operation, 6 and 12 hours after the operation, blood samples will be taken from the patients to determine the hematocrit and hemoglobin, and the amount of bleeding during surgery will also be calculated. Method of measurement: The method of calculating the amount of bleeding during surgery is as follows: each 4x4 inch 8-layer gauze soaked in blood contains 10 milliliters, and each long gauze contains 50 milliliters of blood; So, the number of normal gas soaked in blood is multiplied by 10 milliliters and high gas by 50 milliliters, and the result is added to the amount of blood suctioned. Since this obtained volume includes the volume of washing liquids of the surgical area; The volume of fluids consumed is also subtracted from it and the result is equal to the actual blood loss of the patient.	—

Measure

Time frame

The aim is to investigate the effect of oral drug Inderal on reducing bleeding during hysterectomy surgery. Timepoint: . The first group received oral Inderal 20 mg and the second group received placebo 90 minutes before the hysterectomy surgery. Before the operation, 6 and 12 hours after the operation, blood samples will be taken from the patients to determine the hematocrit and hemoglobin, and the amount of bleeding during surgery will also be calculated. Method of measurement: The method of calculating the amount of bleeding during surgery is as follows: each 4x4 inch 8-layer gauze soaked in blood contains 10 milliliters, and each long gauze contains 50 milliliters of blood; So, the number of normal gas soaked in blood is multiplied by 10 milliliters and high gas by 50 milliliters, and the result is added to the amount of blood suctioned. Since this obtained volume includes the volume of washing liquids of the surgical area; The volume of fluids consumed is also subtracted from it and the result is equal to the actual blood loss of the patient.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Al-Sadat Azimi Abargue

Shahre-kord University of Medical Sciences

dr.maryam.azimi72@gmail.com+98 38 3222 0016

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026