Major depressive disorder. Major depressive disorder, single episode, severe without psychotic features
Conditions
Interventions
Intervention 1: Intervention group (pramipexole): Pramipexole tablets start with a dose of 0.375 mg and if drug tolerance is increased to 0.75 mg in the second week and to 1.5 mg in the third week and
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: The age of patients is more than 18 years and less than 75 years undergoing psychotherapy during the study period Patients with unipolar depression or bipolar patients in the phase of depression or dysthymia Clinical symptoms of anhedonia with a score of 3 or 4 in at least 3 items of the SHAPS questionnaire Patients treated with buprenorphine for at least 4 weeks
Exclusion criteria
Exclusion criteria: History of severe allergic reaction to pramipexole drug or intolerable drug side effects Associated diseases such as hepatitis B and C and liver and kidney failure, uncontrolled thyroid disease, neurological disease, severe asthma and intestinal obstruction. Moderate to severe mental retardation Patients with known and treated dementia Patients with psychotic symptoms breastfeeding Patients needing hospitalization or treatment with ECT according to the psychiatrist's opinion Pregnant women or women who plan to become pregnant in the next few months Presence of suicidal thoughts Simultaneous consumption of psychedelic and hallucinogenic substances Taking drugs that have a significant interaction with Pramipexol, including drugs that cause QT interval prolongation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anhedonia. Timepoint: At entry into the study, week 4 and week 8. Method of measurement: Dimensional anhedonia rating scale(DARS).;Quality of life. Timepoint: At entry into the study, week 4 and week 8. Method of measurement: WHO-QOL-BRE. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHoma Bagheian
Kerman University of Medical Sciences
Outcome results
None listed