Investigating the effect of fluid infusion before spinal anesthesia on headache and low blood pressure after cesarean section

Investigating the effect of intravenous fluid therapy before spinal anesthesia on theoccurrence of headache and hemodynamic disorders in caesarean section candidatesreferred to Amiralmomenin Hospital in 2023-2024

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240904062951N1

Enrollment

120

Registered

2025-08-22

Start date

2025-07-23

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

headache and hemodynamic disorders.

Interventions

Intervention 1: Intervention group: Preloading with intravenous crystalloid (e.g., Ringer’s lactate/normal saline) at [10–15 ml/kg, max 1000 ml] over [15–20 minutes], administered immediately before s

Eligibility

Sex/Gender

Female

Age

16 Years to 50 Years

Inclusion criteria

Inclusion criteria: Candidates for cesarean section under spinal anesthesia Informed consent to participate in the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Incidence of post-dural puncture headache (PDPH) at 24, 48 hours, and days 3 and 7 postoperatively, assessed by patient report and pain intensity using the VAS scale (0–10). Hemodynamic disturbances, defined as systolic blood pressure decrease =20% from baseline, MAP <65 mmHg, or requirement for vasopressors, recorded intraoperatively. Timepoint: Hemodynamic parameters: baseline blood pressure and heart rate measured before spinal block.•Post-dural puncture headache (PDPH): assessed at 24 hours, 48 hours, and on day 3 postoperatively. Method of measurement: Hemodynamic disturbances: Blood pressure and heart rate are recorded using the operating room monitor. A decrease =20% from baseline or MAP <65 mmHg is considered hemodynamic disturbance. The need for vasopressors is also recorded.Post-dural puncture headache (PDPH): Assessed by patient report and pain intensity using the VAS scale (0–10).	—

Measure

Time frame

Incidence of post-dural puncture headache (PDPH) at 24, 48 hours, and days 3 and 7 postoperatively, assessed by patient report and pain intensity using the VAS scale (0–10). Hemodynamic disturbances, defined as systolic blood pressure decrease =20% from baseline, MAP <65 mmHg, or requirement for vasopressors, recorded intraoperatively. Timepoint: Hemodynamic parameters: baseline blood pressure and heart rate measured before spinal block.•Post-dural puncture headache (PDPH): assessed at 24 hours, 48 hours, and on day 3 postoperatively. Method of measurement: Hemodynamic disturbances: Blood pressure and heart rate are recorded using the operating room monitor. A decrease =20% from baseline or MAP <65 mmHg is considered hemodynamic disturbance. The need for vasopressors is also recorded.Post-dural puncture headache (PDPH): Assessed by patient report and pain intensity using the VAS scale (0–10).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPourya cheraghi

Islamic Azad University

Ccp41510@gmail.com+98 21 5534 6301

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026