Effect of Premedication with Ibuprofen and Dexamethasone on Success Rate of Inferior Alveolar Nerve Block for Teeth with Irreversible Pulpitis: A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240830062905N1

Enrollment

Registered

2024-09-23

Start date

2023-06-01

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with irreversible pulpitis. Pulpitis

Interventions

Intervention 1: Intervention group-1: Dexamethasone with single dose of 0.5mg was given orally one hour prior to Inferior alveolar nerve block injections (IANB). Intervention 2: Intervention group-2:

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: patients with pain (VAS=114) in mandibular molar having irreversible pulpitis confirmed by cold test using ethyl chloride, patients who were not taking any antibiotics, anti-inflammatory or analgesics for at least one-week prior to treatment. Both males and females were included age 18-60 years.

Exclusion criteria

Exclusion criteria: 1. Patients with any known allergies Patients with a history of active peptic ulcer Patients with osteoporosis Pregnant or breast-feeding females Patients with immunosuppression

Design outcomes

Primary

Measure	Time frame
Pain reduction. Timepoint: before and after 4 hours after the treatment. Method of measurement: Analogue Pain scale (VAS=3) with scoring 1-10.	—

Countries

Pakistan

Contacts

Public ContactSadaf Amjad

Watim Medical and Dental College, Rawalpindi

sadafamjad986@gmail.com+92 300 5126514

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026