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Investigating the effect of Hydroalcoholic Extract of watercress on Semen Parameters in Infertile men

Investigating the effect of Hydroalcoholic Extract of watercress (Nasturtium officinale) on Semen Parameters in Infertile men before and after: A double-blind clinical trial study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240830062904N1
Enrollment
70
Registered
2024-09-11
Start date
2024-09-22
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility. Male infertility

Interventions

Intervention 1: Intervention group: Capsules containing hydroalcoholic extract of Nasturtium officinale (in the form of 400 mg capsules) 2 times a day and clomiphene citrate (25 mg) once a day. Interv

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 20-45 Years old Desire to participate in the study At least one year has passed since the Decision to have a child and not using Contraceptives during this period Infertile Men have Semen analysis with at least one Abnormal parameter Not receiving any Chemical and Herbal Medicine for Infertility

Exclusion criteria

Exclusion criteria: The presence of epididymo-orchitis (inflammation of the testicles and epididymis) The existence of female causes for infertility Drug addiction and alcohol consumption smoking Having diabetes, kidney disease (creatinine more than twice the normal value), chronic liver disease (transaminase more than twice the normal value) Presence of varicocele Chromosomal disorders Having an anatomical abnormality Contact with toxins, pests, heavy metals and extreme heat Taking antioxidant supplements in the last 3 months Having intense physical activity Having a body mass index higher than 30 kg/m2 History of surgery on the testicles and urinary tract The use of some drugs such as cimetidine, chemotherapy drugs, nitrofurantoin, anabolic steroids and...

Design outcomes

Primary

MeasureTime frame
The percentage of morphology spermatozoa per milliliter of semen in infertile men. Timepoint: Examining the Morphology of semen at the beginning of the study (before the start of the intervention) and 12 weeks after the start of the intervention. Method of measurement: Spermogram test based on World Health Organization criteria.;Volume of Seminal fluid per milliliter of seminal fluid in infertile Men. Timepoint: Checking the volume of semen at the beginning of the study (before the start of the intervention) and 12 weeks after the start of the intervention. Method of measurement: Spermogram test based on World Health Organization criteria.;The percentage of motile sperm (sperm motility) per milliliter of semen in infertile men. Timepoint: Examination of sperm motility at the beginning of the study (before the start of the intervention) and 12 weeks after the start of the intervention. Method of measurement: Spermogram test based on World Health Organization criteria.;Number of sperms per milliliter of semen in infertile men. Timepoint: Examination of semen concentration at the beginning of the study (before the start of the intervention) and 12 weeks after the start of the intervention. Method of measurement: Spermogram test based on World Health Organization criteria.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Fateme Gudarzi

Yasouj University of Medical Sciences

research@yums.ac.ir+98 74 3323 5153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026