Comparing PRP and Tranexamic Acid for Treating Redness After inflammation on the Face

Comparison of the Effect of Platelet-Rich Plasma versus Tranexamic Acid in Post-Inflammatory Erythema of the Face

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240822062839N2

Enrollment

Registered

2025-08-27

Start date

2025-09-23

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post inflammatory erythema. Other specified disorders of the skin and subcutaneous tissue

Interventions

Intervention 1: Intervention group: One side of the face will receive intradermal platelet-rich plasma in two sessions spaced one month apart. Intervention 2: Intervention group: The opposite side of

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with persistent erythema (no improvement in erythema after 3 months)

Exclusion criteria

Exclusion criteria: Pregnant women Breastfeeding women Individuals taking oral contraceptive pills History of known bleeding disorders or on concurrent anticoagulant therapy Individuals using medications that interact with tranexamic acid (TA) Patients who have been treated with oral or topical retinoids in the past month

Design outcomes

Primary

Measure	Time frame
Measurement of post-inflammatory erythema severity. Timepoint: Reduction in post-inflammatory erythema will be measured before the intervention and at 1 month after the intervention to assess treatment efficacy. Method of measurement: standardized clinical photography, dermoscopy with ImageJ® analysis, and CEA/PSA scoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Razmara Farzaghi

Mashhad University of Medical Sciences

razmarafarnaghim@mums.ac.ir+98 915 163 9946

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026