Determining the effects of stopping metformin versus continuing metformin use on kidney function in diabetic patients undergoing elective angiography.
Conditions
Interventions
Intervention 1: Intervention group: Patients who continue taking metformin during angiography. Intervention 2: Control group: Patients who stop metformin 24 hours before angiography and then restart 7
Sponsors
International Research Center of Gilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diabetic people treated with metformin Elective coronary angiography candidate Informed consent to participate in the study People in the age range of 30 to 70 years
Exclusion criteria
Exclusion criteria: Patients who are candidates for emergency angiography Patients who have contraindications for Metformin such as uncompensated heart failure, severe liver disease, severe hypoxemia Acute or chronic metabolic acidosis Failure to fully implement the protocol Glomerular filtration less than 45 ml/min/1.73m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute kidney failure following continued use of metformin during hospitalization for elective angiography of diabetic patients in the form of an increase of more than 25% or 0.3 to 0.5 mg/dL in creatinine concentration compared to the baseline value or decrease in urine output to less than It is defined as 0.5 cc per kilogram for 6 hours. Timepoint: Serum creatinine and glomerular filtration will be evaluated before and 72 hours after angiography in both groups. Also the level of serum creatinine will be re-evaluated one month later to evaluate and compare the return of serum creatinine to baseline values. Method of measurement: Serum creatinine is measured by testing the patient's blood sample and glomerular filtration using the Cockcroft-Gault formula. | — |
Secondary
| Measure | Time frame |
|---|---|
| Metformin-associated lactic acidosis defined as arterial pH less than 7.35 and plasma lactate concentration greater than 5 mmol/L. Timepoint: Serum pH and lactate are evaluated on admission and 72 hours after angiography. Method of measurement: Atrial Blood Gas test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Baharvand
Gilan University of Medical Sciences
Outcome results
None listed