poor ovarian response. Other ovarian dysfunction
Conditions
Interventions
Intervention 1: Intervention group: PRP extracted from the patients own blood sample into ovarian cortex. Intervention 2: Intervention group: Injection of activated platelet-rich plasma with calcium g
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 42 Years
Inclusion criteria
Inclusion criteria: Women aged 20-42 years Three or fewer oocytes retrieved in at least one previous ovarian stimulation cycle and an abnormal ovarian reserve test or an antral follicle count of less than five to seven or AMH <0.5–1.1 ng/mL No fertility problems in the patient's husband
Exclusion criteria
Exclusion criteria: Ovarian failure due to gonadal dysgenesis and chromosomal abnormalities Immunoglobulin A deficiency History of major pelvic floor surgery that has resulted in severe pelvic adhesions. Use of anticoagulants Use of psychotropic medications Presence of psychiatric disorders Cancer History of chronic pelvic pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of eggs retrieved during oocyte retrieval. Timepoint: After oocyte retrieval. Method of measurement: Embryologist report. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anti Mullerian Hormone (AMH) level. Timepoint: Before injection, 1 month after injection and 3 months after injection. Method of measurement: Measurement in blood plasma with ELISA kit.;Estradiol Hormone level. Timepoint: Before injection, 1 month after injection and 3 months after injection. Method of measurement: Measurement in blood plasma with ELISA kit.;Follicle-Stimulation Hormone (FSH) level. Timepoint: Before injection, 1 month after injection and 3 months after injection. Method of measurement: Measurement in blood plasma with ELISA kit.;Antral ovarian follicles count. Timepoint: Before injection, 1 month after injection and 3 months after injection. Method of measurement: Ultrasound.;Number of embryos. Timepoint: 72 hours after oocyte retrieval. Method of measurement: Embryologist report.;Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: Human chorionic gonadotropin (HCG) serum level.;Clinical pregnancy. Timepoint: 5 weeks after embryo transfer. Method of measurement: Observation of the presence of at least one gestational sac within the uterine cavity by ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahshad Khodarahmian
Tehran University of Medical Sciences
Outcome results
None listed