The effect of stem cells therapy in premature ovarian failure(POF)

The effect of Allo/Autolog adipose derived mesenchymal stem cells in premature ovarian failure(POF) 1clinical trail phases

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240815062771N1

Enrollment

Registered

2024-11-15

Start date

2024-10-22

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature ovarian failure (POF). Primary ovarian failure

Interventions

Intervention 1: In a group, they receive autologous cells. After admission based on the inclusion and exclusion criteria and obtaining a consent form at Arash Hospital, fat and blood samples are taken

Eligibility

Sex/Gender

Female

Age

18 Years to 38 Years

Inclusion criteria

Inclusion criteria: Women between 18-38years old with premature ovarian failure(POF) low anti-Müllerian hormone (AMH) levels – 20 IU/l) decreased estradiol levels obtained one month apart(< 20 pg/ml)

Exclusion criteria

Exclusion criteria: Endometriosis Having a history of malignancy polycystic ovary syndrome (PCOS)

Design outcomes

Primary

Measure	Time frame
Investigation of inflammatory factor interleukin-6. Timepoint: before, 24 hours, and 1 month after the intervention. Method of measurement: Real-Time PCR assay.	—

Secondary

Measure	Time frame
Anti Mullerian Hormone. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;Luteinizing Hormone. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;Antral Follicle Count. Timepoint: Before injection, 1 month after injection. Method of measurement: Sonography.;Mature Follicle Count. Timepoint: Before injection, 1 month after injection. Method of measurement: Sonography.;White blood cells. Timepoint: Before injection, 24 hours and 1 month after injection. Method of measurement: Hemoanalyzer.;Pregnancy Rate. Timepoint: 14 days after embryo transfer. Method of measurement: Beta HCG.;Estradiol. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;Folicule Stimulating Hormone. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;TNF-a. Timepoint: before, 24 hours and one month after the intervention. Method of measurement: Real-Time PCR assay.;ESR. Timepoint: before, 24 hours and one month after the intervention. Method of measurement: Enzyme-linked immuno_sorbent assay.;CRP. Timepoint: before, 24 hours and one month after the intervention. Method of measurement: Enzyme-linked immuno_sorbent assay.	—

Measure

Time frame

Anti Mullerian Hormone. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;Luteinizing Hormone. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;Antral Follicle Count. Timepoint: Before injection, 1 month after injection. Method of measurement: Sonography.;Mature Follicle Count. Timepoint: Before injection, 1 month after injection. Method of measurement: Sonography.;White blood cells. Timepoint: Before injection, 24 hours and 1 month after injection. Method of measurement: Hemoanalyzer.;Pregnancy Rate. Timepoint: 14 days after embryo transfer. Method of measurement: Beta HCG.;Estradiol. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;Folicule Stimulating Hormone. Timepoint: Before injection, 1 month after injection. Method of measurement: Enzyme-linked immuno_sorbent assay.;TNF-a. Timepoint: before, 24 hours and one month after the intervention. Method of measurement: Real-Time PCR assay.;ESR. Timepoint: before, 24 hours and one month after the intervention. Method of measurement: Enzyme-linked immuno_sorbent assay.;CRP. Timepoint: before, 24 hours and one month after the intervention. Method of measurement: Enzyme-linked immuno_sorbent assay.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSima Vaez

Iran University of Medical Sciences

info@iums.ac.ir+98 21 8670 2221

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026