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Effect of curcumin-piperine supplementation on oxidative stress in hemodialysis

Evaluation of the effect of curcumin-piperine supplementation Oxidative Stress markers in Patients on Hemodialysis: a double-blind clinical trial study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240809062699N2
Enrollment
70
Registered
2024-09-11
Start date
2024-09-22
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis. Chronic kidney disease, stage 5

Interventions

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Hemodialysis for minimum 3 months Normal Gastrointestinal system & absence of GI complaints Tendency to participate in study No-entry of patients with bleeding tendency, eg, Aspirin or Warfarin or NOVAK use No-entry of patients with hepatobilliary diseases No-entry of patients in Immunosuppressive drugs

Exclusion criteria

Exclusion criteria: Pregnant or lacating patients Dont tendency to participating Observation of any side effects, develop any non-entry conditions during the study Consumption of less than 90% curcumin-piperine supplement Side effects that can lead to stopping the plan or withdrawing the subject from the study after taking the supplement Causing any unwanted digestive problems including stomachache, heartburn, nausea, vomiting, diarrhea or others Causing any kind of sensitivity in skin, respiratory or otherwise Any side effects that did not exist before taking the supplement History of allergy to turmeric compounds Active cancer Recent surgery

Design outcomes

Primary

MeasureTime frame
Total antioxidant capacity (TAC) serum level. Timepoint: Begining and three months after starting to take the supplement. Method of measurement: ELISA.;Superoxide Dismutase (SOD) serum level. Timepoint: Begining and three months after starting to take the supplement. Method of measurement: ELISA.;Malondialdehyde (MDA) serum level. Timepoint: Begining and three months after starting to take the supplement. Method of measurement: ELISA.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFirouzeh Moeinzadeh

Esfahan University of Medical Sciences

f_moinzade@med.mui.ac.ir+98 31 3822 6713

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026